Tenderly fragile

A few days ago we had our biweekly science operations meeting. Towards the end of it, one of my colleagues mentioned that the INTEGRAL Picture of the Month for December would be the obituary. “Obituary!?! For whom!?!”, I asked, with surprise and a little anxiety. “You didn’t know? Mike died last week”. It came as a slap in the face. I had no idea he was ill. And obviously, I had no idea he was dying. He was 42.

Mike and I met in Moscow in 2006 at the 6th INTEGRAL Workshop. I had read his papers, and he had read mine, but we had never met. There was a tension between the Russians and the rest of us. The reason is mostly related to the fact that 1) Russian scientists, formally can, and in practice do, work and share data or analysis results only with other Russians; 2) the Russian space agency put INTEGRAL into orbit, and in return, negotiated with ESA to get one quarter, 25%, of the observing time for the lifetime of the mission; and 3) more specifically related to the topic of my own research, the Galactic Centre, the head of the Russian delegation, the great and famous Professor Sunyaev, had negotiated to get half the observing time on this region, and therefore, share all the data half way down the middle with the official Principle Investigator for the Galactic Centre, my PhD co-supervisor, Andrea Goldwurm. So, there were subtle but definitely palpable tensions.

Professor Sunyaev gave a stunning presentation in which he talked about the science that could be and was being done with INTEGRAL data, he drew on his vast mastery of all fields of physics, making analogies, explaining connections, and clarifying issues that most of us could not even see, freshly and spontaneously, without any arrogance, in a simple matter-of-factly kind of way. I was immensely impressed. His was a 40-minute review talk. Mine, on the same day, was a 30-minute presentation, which was also a long one, since the programme contained mostly 20-minute presentations, invited review talks of 40 minutes, and a handful of 30-minute presentations. I gave a shortened version of the talk I had presented in the main amphitheatre of the CEA two months before to my PhD defence committee, and the public in attendance.

Everyone was very impressed, I think because, unlike anything I’ve ever seen at such a scientific conference, the first 10 minutes were spent with my narrating a Discovery Channel video of an voyage through the Galaxy, from the Earth to the Galactic Centre, that I slowed down to give myself enough time to describe the large scale structures and global features of our Galaxy, the distribution of stars and gas that make up its visible contents, talk about their formation and dynamics, about open and globular clusters, types of stars and their different life cycles, about planetary nebulae and supernovae remnants, magnetic field structures betrayed by particles trapped spiralling along them and seen at radio wavelengths, and on and on.

It was during the break after that session that Mike came up to me for the first time. He was bright, quick, sharp as a whistle, energetic and curious, open and friendly, but serious. He had a kind of grave seriousness to him. All these qualities appealed to me. He complimented me on the presentation, and we talked for a few minutes. What struck me most was that he was simple and straight forward: not puffed up, not arrogant, not condescending; and not cautious, hesitant, distant, or reserved either. Just open, simple, and straight forward: nothing hidden, nothing fake. I’m like that too. We connected.

Later that night, we had the banquet dinner, and we spoke a lot more together after eating. Naturally, given that we were in Moscow, everyone (or almost) drank plenty of wine with dinner, and everyone (or almost) was now drinking vodka. Conversations and laughter flowed freely and echoed in the large hall. Mike invited me to come out in the evening, and meet him with other people at a bar where we could watch, while chatting, the football game. It was the time of the 2006 Football World Cup, and this is what defined the plans for the evenings. I agreed, and we spent the evening together.

When it was time to call it a night, after all buses had stopped their service, he offered to walk back with me from the bar to the hotel. I gladly accepted. It was a 45 minute walk across the city, which I didn’t know at all, but which was his beloved home town. So somehow, in those few days in Moscow, we became friends. Friends who didn’t really know much about one another, but friends that connected on a deeper level. These things are hard to explain, and have to do with personal traits and upbringing, tendencies and sensitivities, affinities and outlook. The few other times we saw each other, either at conferences or meetings, it was always the same. We saw each other for a short time,  didn’t really have much to talk about because neither of us liked small talk, but we felt happy to see one another. We exchanged a few Skype chats over the years, but that was the extent of our relationship.

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And when I heard that he was dead, I was shocked. What first struck me with sadness is that there was no way for me to express to him how I felt about him, and how sorry I was that he was gone. We often hear of someone’s passing after they have already passed. This makes it impossible for us to express anything to them: no expression of kinship or feelings of empathy, no sentiments of understanding at what they are going through, no words of support, comfort, or warmth. Nothing more can be expressed to them because they are gone. Tears welled up in the eyes. Impossible to say anything. Impossible to write anything. Impossible to reach him. Impossible, now and forever. Feeling sad and helpless, I sat in silence, tender and fragile.

This is what we are: tender and fragile. It’s just that most of the time we don’t realise it, nor do we think about it. When it hits us, and we feel it for a fraction of a second, we push it away, push it down under the shell that we think hides and protects us.

Looking at people every day, friends, colleagues, and strangers, I see so many signs of illness: I see people with the white of their eyes a yellowish colour, with the skin of their face a pale grey; I see dry and dull skin, rashes on the face, or the neck, or the scalp; I see hands and fingers that tremble with uncontrolled tremors when they should be still and unmoving; I see teeth that through a smile can be discerned to be capped by crowns, because they are too white, sitting on top of what are surely devitalised, nerveless, root canal treated teeth, whose dark colour lines the base of the tooth; I see young women with white faces, blueish hued skin under their eyes, sparse and thinning hair, feeling cold and looking down; I see young men with pudgy little man boobs, and men in their 50’s with sparse, balding eyebrows; I see bodies, full of fat, fat that is pressing in, compressing their vital organs, their heart, their liver, their stomach and pancreas. And on, and on. So much disease everywhere, and nothing to be done for these poor people. Nothing to be done because they don’t know, and because they don’t want to know.

Could I have helped Mike? I’m sure I could have. Did he ever share with me anything about his illness? Did he even know I knew anything about health and disease? No, he didn’t. And all these people I see every day? All these people with dehydrated bodies filled with accumulated metabolic wastes, acids and toxins, with undiagnosed intolerances and allergies, with severe B12 and magnesium deficiencies, with bacteraemia from toxic teeth, with serious iron and iodine deficiencies, with testosterone deficiencies and oestrogen overabundances, with extreme insulin resistance and metabolic syndrome, all sick and unaware of it. And what about all those with diabetes and cancer, diagnosed and yet undiagnosed? Is there anything I can do for them, no matter how sad I feel, or how much I would like to? No, there isn’t, because it is they who need to look for it, they who need to want to do something about it. And how can they if they don’t know, or even worse, don’t want to know?

And so, little by little, a little better every day, I learn to live with this. This which we all fundamentally are, whether we allow ourselves to realise it or not, whether we allow ourselves to feel it or not, and whether we want to or not, this is what we are: tender and fragile, tenderly fragile.

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You have cancer, and there’s lots you can do

Everybody knows that cancer rates are rising everywhere and every year. Everybody also knows that the words, “You have cancer. I am sorry.”, fall upon us like a death sentence. Everybody knows this, because we see it all around us, everywhere we look, and we hear about it every day, everywhere we turn.

If a doctor has, indeed, said these words to us, then we are probably scared, probably very scared. We know that basically everyone we have ever heard of who were diagnosed with cancer, died. Sometimes they died really quickly, like, within a few weeks. Sometimes they died within a few months. Sometimes it wasn’t so quick. Maybe it took a year of two, or three, or even five. They went through rounds of chemo. They were on sick leave at home for months on end. They sometimes appeared to recover at some point, maybe a bit, for a little while, but in the end, they died. And they died of cancer.

We also know that not even the most famous and richest people, like Steve Jobs, for example, can escape this kiss of death that the diagnosis of cancer delivers. Wealth and power are irrelevant when it comes to our prognosis as cancer patients: it is always bad. Of course, how bad it is depends on the kind of cancer, but why is it that so many different people, in so many different places, die of cancer every day?

I won’t venture into formulating an answer to this question, and I won’t dwell on cancer survival statistics. I don’t think it’s useful for us right now. I want to hurry and move to the good news. And the good news is that there many things you can do to help your body rid itself of cancer, which is usually the result of a long-standing disease process that has evolved over a lifetime, and has finally manifested itself in this way. This presentation of the question at hand is definitely not exhaustive, nor attempting to be. But this is what I consider to be some of the essential elements.

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White blood cells (shown in blue) attacking cancer cells (shown in red).

 

Understanding cancer

To understand cancer, we have to understand the origin of cancer cells. Cells become cancerous due to a defect in energy production, a mitochondrial dysfunction, an inability to manufacture enough ATP (adenosine triphosphate) through oxidation of glucose or fatty acids to sustain the cell’s functions. This forces the cell to fall back on anaerobic (without oxygen) fermentation of glucose to supplement the deficient energy production from the dysfunctional or reduced number of mitochondria. Fermentation produces an increase in lactic acid in and around the cell. This decreases the availability of oxygen to the mitochondria, which further impedes their ability to produce ATP through oxidation of nutrients, and creates a negative feedback loop that pushes towards further mitochondrial stress and dysfunction, less oxidation, more fermentation, more acid, and less available oxygen.

Because energy production through fermentation is so very inefficient, the cell needs far more glucose, and naturally develops more insulin receptors in order to be ever more sensitive to, and able to capture circulating glucose more effectively. Cancer cells often have 10 times more insulin receptors than healthy cells. What should be clear is that it doesn’t matter where the cancer is, and it doesn’t matter how it evolved, whether it was due to a gradual evolution from an environment too high in glucose, lacking in oxygen, and saturated with acid, or whether it was due to exposure to a toxin or mitochondrial poison, of which there are many and increasingly more in our environment. In the final analysis, this is how cancer cells become how they are, and this is how they survive.

As to their multiplication and proliferation from a single or small group of microscopic cells to large macroscopic tumours in one spot or all over the place, this can be understood by considering that the cell that is devolving from its normal function to that of cell whose only function is to ferment glucose at the fastest possible rate, loses, little by little, the ability to do whatever it was doing before, by losing the ability to produce ATP that can be used by its different specialised parts and constituents to perform their specialised functions, the cell becomes less and less specialised, less and less differentiated and therefore more and more general and more and more primitive, to the point where the essential ability of the cell to destroy itself, when something in its workings has gone wrong, is lost. Having lost this safeguard, the primitive, the undifferentiated, but also necessarily abnormal and weakened cell, just ferments and multiplies, limited only by its ability to fuel itself and sustain this most basic activity of survival without other purpose but this survival in and of itself.

Removing cancer

Having recognised and understood this, the strategy by which we can help the body rid itself of the cancer cells, and regain its healthy physiological functions becomes clear. We have to 1) do all we can to cut off the source of fuel to the cancer cells, 2) clear out the accumulated acids and transform the acidic environment into one that is alkaline and oxygen-rich, 3) help restore the cells’ mechanism of apoptosis—their ability to self-destruct, and 4) do everything else we can to further weaken and destroy cancer cells by means that simultaneously strengthen healthy cells. It’s a simple strategy that is also simple to put into practice, as we will see in a moment.

1) Starve the cancer cells

The first point is to cut off the fuel to the cancer cells. The source of fuel is glucose, because cancer cells can only ferment and cannot oxidise, and the way the glucose is supplied to the cell is by the action of insulin that moves it across the cell membrane. Therefore, what has to be done to is minimise the availability of glucose, and, more important still, minimise the availability of insulin to shuttle the glucose into the cells. The lower the glucose, the less potential fuel there will be. The lower the insulin, the less glucose will actually be able to enter cells. There is no real lower limit. Without ingesting any carbohydrates, the body maintains and regulates blood sugar according to the stress levels and kinds of activities we engage in, independently of how low insulin levels are. And so, the focus should be to have the lowest possible insulin levels naturally.

The fastest way to lower blood sugar, but especially insulin, is to fast, to stop eating altogether, and just drink water and herbal tea, remembering to eat enough salt to match the water intake. The second best way of doing this is in form very similar, but turns out to be much easier to do, is also a kind of water fasting, but with the addition of fat from coconut oil and butter, melted in the herbal teas. Both of these forms of fasting will most effectively deprive the body of anything that can easily be made into glucose, and of anything that will stimulate the secretion of insulin, thereby will allow glucose to drop as low as possible, but more importantly, insulin to drop and stay at an absolute minimum, and therefore most effectively starving cancer cells, no matter where they are in the body and bodily fluids, in the tissues and organs. The first form of the classic water fast is harder, but many people do it without hesitation nor difficulty. The second form is much easier, and may even be more effective in inducing a deep state of ketosis given the additional intake of medium chain fatty acids.

We can easily imagine doing such a fat “fast” for days, or even weeks, depending on the severity of the situation, our resolve to suffocate and starve the cancer cells as quickly as possible, and, of course, the state and circumstances in which we find ourselves. In addition, we can do this as much as possible on any given day, independently of what else we eat. The more fat and the less carbohydrate we ingest, the lower the insulin and the more effective the anti-cancer healing protocol will be.

The third option is to eat and drink to keep insulin levels as low as possible. Here again, because fat is the macronutrient that stimulates the least secretion of insulin, truly minimal, it should be the main source of calories. Simple carbohydrates and starches are most insulinogenic, and protein is about half as insulinogenic as are carbs. Indigestible fibre does not stimulate insulin. Therefore, in the extreme, we would eat only fat, pure fat. The best ones being the most natural and least processed, most saturated and least unsaturated: coconut fat, butter, animal fat and, the best of the vegetable oils, cold pressed olive oil.

It’s important to understand the difference between having low blood sugar, and having low insulin levels. The first is like the amount of food in the kitchens of the restaurant, the second is like the waiter bringing it to the table. It is far, far more important in our efforts to stop the supply to cancer cells that we keep insulin levels as low as possible, than it is to try to keep glucose levels low. And to push the point further, it doesn’t really matter what the amount of glucose actually is, because as long as insulin is low, it will not be brought into the cell, into the cancer cells. The reason I emphasise this is because lack of sleep, emotional or psychological stress, intense physical exercise will all raise blood sugar levels temporarily, in some instances, to high levels. But as long as insulin is as low as it can be, the sugar will not be readily transported into the cells.

Naturally, we cannot have zero insulin, because we would die: our cells would literally starve to death, no matter how much we ate. Babies with a genetic defect that makes their pancreas not able to produce insulin always died of emancipation before the discovery and subsequent commercialisation of insulin as medicine. Similarly, if at any point in a child’s or adult person’s life, insulin stops being produced, incredible weakness and emancipation will follow, before it is tested and identified as the cause of their problem, hopefully in time before permanent damage ensues. Therefore, there is always some insulin in circulation, and therefore, sugar will eventually make its way into at least some cancer cells. This is why it is important to keep it as low as we possibly can naturally, and this is how we can appreciate the essential difference between the effects of high glucose and high insulin.

In a less extreme form than the fat-fast, we maintain low sugar and low insulin by getting and deriving most of our energy from fat. Eating cucumber or celery with almond butter or tahini, for example, or a green leafy salad with lots of olive oil, walnuts, and avocado, provides basically all calories from the fat, given that cucumber, celery and lettuce greens, are basically just water and indigestible fibre, while almond butter and tahini are 80\% fat by calories, and walnuts are 84\%. So is coconut milk, for example, at nearly 90\%, and dark 85\% chocolate, at 84\% fat based on calories. Focusing on feeding the body with these kinds of healthful, high-fat foods, will nourish, stimulate healing, and keep insulin and glucose levels as low as we can without either water fasting, or consuming only fat.

2) Alkalise to remove and excrete accumulated acids

The second point is just as important as the first, because it is the environment in which the cells live that actually has the most direct effect on their function. We have looked at the importance of achieving and maintaining an alkaline environment in the body in several other places. The essence is excellent hydration with alkaline water (pH>8) combined with the intake of proportional amounts of unrefined salt to promote the release of acids from the tissues, and its excretion through the urine by the kidneys. Without proper hydration, the cells will retain the acid with the little water they have to hold on to. Without proper amounts of salt, the kidneys will also retain the acid in order to maintain the concentration gradient that allows the nephron to function when it re-absorbs water.

Naturally, alkaline water will work infinitely more effectively. But the most important detail is the controlled balance between water and salt intake, and what we want is a lot of water and a lot of salt. We cannot take in large amounts of salt water without getting loose stools. So, it has to be smoothly distributed throughout the day, except in the morning, when we get up, because we are dehydrated, and need to drink about 1 litre of water over the course of one to two hours, before we start taking salt.

If you buy mineral or spring water, find the one that has the highest pH value. It should be greater than at least 8. If you have a water filter at home, then add alkalising drops to it before drinking it. I use Dr. Young’s PuripHy drops.

As acidity decreases, and the environment becomes more alkaline, oxygen will flow more freely, and become more available to mitochondria for oxidising fatty acids in producing energy. Remember that cancer cells do not use oxygen, and cannot use fatty acids to fuel themselves, whereas normal, healthy cells, not only can, but function much more efficiently on fat rather than glucose as their primary fuel. Adding chlorophyll and fresh juice of green vegetables to the alkaline water is an excellent way to further boost alkalisation, neutralisation, and elimination of accumulated metabolic acids. Unlike the first step, which is to lower insulin and glucose levels, and that can be done, to a great extent, literally overnight under fasting conditions, alkalising to eliminate accumulated acids is something that takes time. But in both cases, what matters most is consistency. Hour by hour, and day after day, the body will do what it needs to do as best is can, and improve in these functions with time.

Beyond this fundamental necessity to hydrate with alkaline water throughout the day, and day after day, the most therapeutic way to alkalise the tissues, and detoxify the body, is by taking medicinal baths in which we add two cups of sodium bicarbonate (baking soda), and two cups of magnesium chloride (nigari), or magnesium sulphate (epsom salts), if nigari is not available. This is easy, relaxing, extremely medicinal, and very effective in neutralising and eliminating acids and toxins from the body. In fighting cancer, you should be soaking in this kind of hot bath for 45-60 minutes three times per week. The benefits of this ultra simple trans-dermal therapy with sodium bicarbonate and magnesium are incredible. You can read a lot more about this from the baking soda, magnesium and iodine doctor, Dr Sircus.

3) Restore cellular self-destruct function

The third line of action is also essential, and it only requires you to take a few key supplements. The most important of these in the fight agains cancer is iodine, because of its fundamental role both in the structure and architecture of cells, but also in the regulation of apoptosis, the process by which a damaged cell will self-destruct when things have gone wrong somewhere. The importance of iodine cannot be overemphasised. And in healing cancer, or any serious disease condition, we will want to take high doses daily. Doses of at least 50 mg, but preferably 100 mg.

However, because of its very strong detoxification effects, as it pushes out all accumulated toxic halogens out of the cells to replace these by iodine in its proper place, we must work up to these high doses gradually, starting with 12.5 mg, and increasing the dosage as quickly as possible given the body’s response to it. Some people , maybe most, will experience headaches and possible nausea when starting on iodine. This is perfectly normal. The stronger the reaction, the more indicative of the body’s level of toxicity. Therefore, you should always view this as something good, in that toxins are being excreted out of your cells. It is important to support the detoxification process by taking chlorella and spirulina, probiotics and psyllium husks every day as well, while always drinking a lot of alkaline water with added chlorophyll for extra cleansing, if possible.

What I take and consider to be the best supplement is Iodoral by Optimox. Optimox recommends taking the iodine on an empty stomach for faster absorption, but it can also be taken with food for slower and possibly better assimilation. In addition, although iodine can easily be taken on an empty stomach, the co-factors, which include B vitamins, are much better taken with food to avoid potential nausea or queasiness. Moreover, taking it with food will slow down the absorption, and thereby decrease the negative sensations from the detoxification effects. The only thing is that iodine, given its stimulation of thyroid function, will energise the body. Therefore, it should be taken before midday. I take it either first thing in the morning or at lunch (or both).

You can read about the importance and functions of iodine in the following three books: Iodine, Why You Need It, Why You Can’t Live Without It by Dr. Brownstein; What Doctors Fail to Tell You About Iodine and Your Thyroid by Dr. Thompson; and The iodine crisis: what you don’t know about iodine can wreck your life by L. Farrow. There are also many web resources and highly informative forums about iodine and cancer. You can search for the words iodine and cancer to see for yourself.

Other fundamentally important micronutrients are vitamins B12 and D, both of which are needed for proper cellular function, and DNA transcription and replication, because of their roles in the nucleus of cells, activating and de-activating, switching on and off genes, to ensure everything in the cell works as it should. For best and fastest results—and that’s definitely what we need in our fighting cancer—B12 should be injected weekly in the amount of 1 mg, and in the form of methylcobalamin. (For optimal health in normal circumstances, it can be injected once a month in the amount of 5 mg.) Vitamin D should be taken with its sister vitamins, A and K2, for synergistic effects and biochemical balance in their functions. Each of these have complimentary roles, and should generally be taken together, unless there is a reason not to. You can read these two articles published by Chris Masterjohn from the Weston A. Price Foundation to learn why and how: On the trail of the elusive X-factor: a sixty two year old mystery finally solved, and Update on vitamins A and D.

It is by supporting proper cellular function, especially in the nucleus, with iodine, B12 and D, that cells will regain, little by little, the ability to recognise that they are damaged and need to self-destruct. There will always be millions or even billions of cells involved in the disease process we call cancer, but they will be distributed along a wide spectrum of dysfunction, from having very mildly impaired mitochondrial function from a light oxygen deficit cause by a little too much acid in the environment surrounding the cell, to full cancer cells that derive 100% of their energy needs from anaerobic fermentation without using any oxygen at all, and thriving in extremely acidic conditions.

Hence, many cells will die from being starved of glucose, because that’s the only fuel they can use; many cells will recover enough of their normal regulatory mechanisms to know its time to self-destruct; and many cells will actually regain their healthy function, repair their damaged parts, and replace their dysfunctional mitochondria with new ones. Nothing is ever black and white when it comes to cells and cellular function. Instead, everything is grey. But it is a million different shades of grey.

4) Do everything else that can help

The fact is that there are many, many more things you can do. Many therapies, many treatments, many supplements and herbal formulas, that have all proved highly effective against cancer. There are so many that many books have been written about them: About Raymond Rife, you can read The Cancer Cure That Worked by Barry Lynes; about Gaston Naessens, you can read The Persecution and Trial of Gaston Naessens: The True Story of the Efforts to Suppress an Alternative Treatment for Cancer, AIDS, and Other Immunologically Based Diseases by Christopher Bird; about Rene Caisse and the Essiac tonic, you can read Essiac: The Secrets of Rene Caisse’s Herbal Pharmacy; about Johanna Budwig, you can read Cancer – The Problem and the Solution; and the list goes on. There are websites devoted to these people and their approach to cancer, and this is just a few of them that I know about. One book that compiles a lot, maybe most, of the information on non-toxic treatments for cancer, is Ty Bollinger’s Cancer: Step Outside the Box.

Maybe you find it hard to believe that our governmental and medical authorities would have gone—and continue to this day—to go through such extreme measures in order to suppress treatments that work so effectively to help and heal people of their illnesses and of cancer, without negative side effects, and at very low costs. But this is a simple fact. And it is quite easy to understand if we consider that anyone, or any institution, that has commercial investments and interests in a particular endeavour, will go to great lengths to maintain and strengthen, as much as they can and for as long as they can, the conditions that make them successful. There’s nothing more to it than that. Let’s look at a few of those therapies and supplements which are easy to implement, and highly effective against cancer: hyperthermia, flax seed oil, enzymes, and turmeric.

Hyperthermia, or heat therapy, is a very well studied and effective therapy against cancer, both preventatively and curatively. The idea or principle is very simple: healthy cells can withstand high temperatures without damage. The reason why this is so, and why we know it for sure, is that the body produces fevers as a defence mechanism to destroy invading viruses and bacteria that, unlike our own cells, cannot withstand the heat. Similarly, cancer, and other compromised and damaged cells, are unable to cope with high heat. Hence, it was hypothesised, tested, verified and demonstrated that hyperthermia is really very effective at destroying cancer, while simultaneously cleansing and strengthening healthy cells and tissues. Infrared saunas are ideal in heating the tissues more deeply, but any sauna, steam room, or even bath that induces hyperthermia by raising the temperature in the body, will help kill cancer cells, cleanse, and restore health.

Enzyme therapy has also been used for many decades in the treatment of cancer patients extremely successfully. The late Nicolas Gonzalez who passed away last year, was its most recent champion, following in the footsteps of his mentor, Dr William Kelley. The treatment protocols are more complicated, and are always highly individualised, but the main element is the supplementation with large doses of enzymes, combined with the colon cleansing to eliminate the dead tumour tissues from the body. Large quantities of fresh vegetable juice are also often included in his recommendations. You can read about it here: http://www.dr-gonzalez.com/index.htm, but whether you decide to throw yourself completely into it or not, I strongly recommend taking proteolytic enzymes three times per day, always on an empty stomach at least 30 minutes before eating, and support cleansing by taking a colon cleanser before going to bed. This site, http://www.losethebackpain.com, has good quality enzymes and cleansing supplements that we’ve used, but you can also do your own research.

Flax seed oil, organic and cold pressed, combined with fresh organic quark or cottage cheese is, based on Johanna Budwig’s extensive, lifelong research, as well as practical clinical experience with patients, is another one of the most effective and simple cancer treatments. And although the biochemistry of it, and biochemical pathways through which the cancer is weakened and destroyed may be complicated, the implementation is very easy and simple, costs very little, and cannot in any way bring about harm, unless one is severely allergic to milk proteins (in which case the dairy can be replaced with another source of protein that will work as the carrier). Here is a good article that has links to other excellent articles about this: https://www.cancertutor.com/make_budwig/

Turmeric, an ancient, bright yellow, Indian spice, which is a powder made from drying the ginger-like root that is turmeric, is one of the most researched natural substances in modern times, and is surely one of the most powerful natural anti-cancer supplements. Since it has tons of wide-ranging health benefits, and carries no risks at all, it’s clear that everyone can benefit from it. You can read about it from Mercola here. You should take it three times per day, but with your meals, because the more fat there is in the gut, the better the absorption will be, as is true for most antioxidants, vitamins, and minerals.

I feel it is important to emphasise the point just made about the risk-free nature of supplementing with turmeric, because it is a crucial point that applies to everything we have discussed here, and everything we have discussed in all the natural healing protocols and nutritional approaches we have presented in the past. Food-based nutritional healing is, in general, risk-free, because it doesn’t involve ingestion of or exposure to toxic substances, and instead involves correcting deficiencies, boosting nutritional status, and optimising the biochemical and hormonal environment of the body in order to promote healing.

Of course, we can object by referring to examples of people dying from drinking too much water too quickly. But we are not talking about such extremes. Nonetheless, we could, for example, eat coconut oil or butter all day, and other than the possible nausea from taking in so much fat, you wouldn’t get anything more than loose stools. Moreover, the body’s own hormonal responses would naturally prevent overconsumption through a feeling of extreme satiety that would basically make it impossible to willingly eat more.

Another example is that of using baking soda or iodine. So simple, and yet so powerful, they stand as the perfect examples of the benign nature but extreme effectiveness of natural healing. We find written in the most recent edition of the Manual for the Medical Management of Radiological Casualties of the US Military Medical Operations, Armed Forces Radiobiology Research Institute, that sodium bicarbonate will “prevent deposition of uranium carbonate complexes in the renal tubules”, and that we should, “within 4 hours of exposure, administer potassium iodide (KI) to block uptake of radioactive iodine by the thyroid”, because they are the best known ways to protect the kidneys and thyroid from being destroyed by the radioactive elements that would—without the use of sodium bicarbonate and potassium iodide—migrate to these organs and destroy them.

But why wait for a chemical spill or a nuclear power station meltdown in order to rid the body of accumulated chemicals and toxins, and to replenish every cell with a plentiful supply of iodine to ensure that all cells and all glands function at their best, now and every day? We don’t have to wait. The same goes for turmeric, for enzymes, for B12, for A-D-K2, for hydration, for alkalisation, for minimal glucose and minimal insulin loads, for maximum nutrition and maximum health. Why don’t we start doing this preventatively right now?

Summary and Wrap up

Maybe you know all of this stuff already, or maybe you don’t and you are blown away and overwhelmed by the amount of information and range of topics we have covered. Maybe you are reading this because you are interested and curious to learn and be as well-informed as you can about health topics, or maybe you are desperately looking for relevant information that can help you or a loved one. No matter in which camp you find yourself, here is the summary and wrap up I can offer to bring all of what we have discussed down to a simple set of recommendations that anyone faced with a diagnosis of cancer, and fearful of, or skeptical about, or doubtful that the current standard of care in the cancer industry will help them, can understand and follow, knowing that none of these food choices, supplements, and therapies will bring them harm in any way, and that all will only do good, regardless how dire or hopeless their situation may appear to be.

  • Keep low insulin levels, as low as possible, by not having insulin-stimulating carbohydrates, and by keeping protein intake reasonably low. Focus on consuming natural, unprocessed fats as much as possible to supply the largest proportion of your daily calories. Consider a water or a tea-with-fat fast for a few days when it is suitable, or even as an intermittent fasting strategy on a daily basis. Consider also doing a green juice “fast” (only green vegetables) with added fat from blending in melted coconut oil or milk.
  • Drink alkaline water, always on an empty stomach, considering the day as divided between hydration periods, and feeding and digestion periods. The first hydration period is from the time you get up until you have your first meal. It is good to extend that period if you can to allow plenty of time for proper hydration after a long night of dehydration, with at least 1 to 1.5 litres over a period of at least 2 hours. Drink slowly to improve absorption and not pee everything out. Always allow 30 minutes without drinking before meals, and 2-3 hours after meals, depending on their size. The cycles of hydration and feeding during the day (for 3 meals) should be as follows: drink, wait, eat, wait, drink, wait, eat, wait, drink, wait, eat. For only two meals, which I recommend, then periods of drinking are extended and allow for even better hydration, cleaning of the blood, and better digestion.
  • Take iodine supplements with the co-factors and with food to maximise absorption and effectiveness. Start with 12.5 mg per day, and work your way up to 100 mg. Do this as quickly as your body allows you to. Take the iodine every weekday, and stop on weekends; five days on, two days off. (My wife and I take 50 mg per day.)
  • Take hot baths with sodium bicarbonate and magnesium chloride (or sulphate; 2 cups of each). Soak for 40 to 60 minutes. Do this three times per week. Always take your baths on an empty stomach, and drink at least one litre of alkaline water during the length of the bath. (Once per week is what I aim for as preventative medicine.)
  • Get B12 injections of methylcobalamin, 1 mg on a weekly basis. (My wife and I get a 5 mg injection once per month.)
  • Take proteolytic enzymes and Essiac tonic three times per day, always on an empty stomach, always at least 30 minutes before meals. (We take it once, first thing in the morning.)
  • Take turmeric and turmeric extract, as well as A-D-K2 with every meal or fatty snack, three times per day during recovery. (Once daily in normal circumstances.)
  • Take infrared or regular saunas, every day if possible, or even in the morning and at night if you have or decide to buy your own little sauna. I would definitely do this given how effective hyperthermia is at destroying cancer cells.
  • Eat Budwig cream.
  • Eat and drink greens.
  • Spend time outdoors, as much time as you can, moving, breathing fresh air, exposing your skin to the sunlight.
  • Keep low stress levels, as low as possible. Take tulsi, ashwagandha, and HTP-5 to keep stress hormone levels low, and mood high.
  • Take probiotics, chlorella and spirulina in the morning, and a colon cleansing supplement before bed.
  • Sleep well, long restful nights. Melatonin is very useful for this, and has many additional health benefits.

Cancer is very easy to prevent, but somewhat harder to dislodge once it has taken hold somewhere within the body. But no matter what type of cancer, how localised or generalised it is, or at what stage it finds itself, there is always hope. Hope of getting better and more comfortable, and hope for a complete recovery.

We have to remember that cancer cells are degenerate and weak. By making the environment as health-promoting to normally functioning cells, and simultaneously as hostile as possible to cancer cells, they will perish and be cleared out from the body as the waste that they are. The body heals itself, often miraculously quickly, when impediments are removed, and the elements needed for healing are provided. With all my heart, I hope this can help you and your loved ones.

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Is it really a fault in our stars?

childrenLookingAtNightSky

All these stars, these countless stars we see in the sky at night, are the souls of little children waiting to be born. When a mom and a dad love each other and get married, a star comes down and an angel brings one of these little souls into the belly of the mom. Then, it grows into a baby and, after 9 months developing inside the mother, comes out and becomes a sweet little child like you.

This is what my mother explained to me when I asked her where children came from. I don’t know if this is a popular story, one that many parents tell their children when they ask them where they came from, but it is a sweet little story that happens to be far easier for a young child to understand than how things really happen. It also transmits a sense that each child, the life of each child, is magical and mysterious in origin, and therefore incredibly special. This is true: Life is magical, its workings are mysterious, and it is on the whole truly amazing.

A few nights ago, on new year’s eve, out son went to sleep over at a friend’s house, to watch a film (2001 Space Odyssey) and ring in the new year. My wife and I stayed home and watched a movie together. We watched The Fault in Our Stars, Josh Boone’s film of John Green’s book that our son first read and then watched, and highly recommended.

It is a touching story about two young people, Hazel-Grace and Augustus, that fall in love, with one another, deeply and sincerely in love. But their friendship lasted a very short while only because of Augustus’s quick, and in some ways, unexpected passing away. Hazel and Gus met at a meeting of a cancer support group where he went to accompany his best buddy who had recently learned they were going to take out his second eye due to the spread of his childhood retinoblastoma, and where she went to please her mother who insisted she go to meet people with whom she would have at least one thing in common: her life-altering and debilitating childhood cancer.

Hazel developed lung cancer when she was around 13, and lost one of the two lungs some time after that, and was, since then, living with a small oxygen tank she had with her at all times throughout the day and night, a little tube bringing oxygen into her nostrils, providing her with the oxygen she needed to survive. Augustus right leg had been amputated due to an aggressive cancer a few years back, but looked to be in very good spirits, an inspired and inspiring young man. I won’t say anymore about the film because you really should watch it for yourself. It is very good.

The picture that is painted of the world seen through the eyes of these young people is indeed very different from what most of us who do not suffer from serious illnesses are accustomed to. They know very well and unambiguously not only that their days are counted, but also that the end can come at any time, even without a moment’s notice, today or tomorrow, next week, next month or next year, but surely and without a doubt about it. They know and have in the forefront of their consciousness the unavoidable fact they they are dying, that they are at the mercy of death.

The truth is that this is also true for everyone everywhere. It’s just that the perception of it and the timescale are different, or at least it tends to be: before being afflicted or diagnosed with a typically deadly disease like cancer, we tend to act and think that we will live forever, or at least for so long that it’s really not relevant to consider how long because we’ll be old and frail and our children will have families of their own, and our grandchildren will themselves already be grown ups, and on and on; after becoming seriously ill or receiving a crippling diagnosis, we immediately see the end, we see our end, as something actually really close to us, and, unfortunately unavoidable.

Even if the film is very sad, it is also very inspiring, giving us, all of us who are still alive, so much to be thankful and grateful for. This is what I felt. And this is what I said to my wife as we were lying in bed before falling asleep, after the distant fireworks and local firecrackers had finally subsided: we are just so lucky, so incredibly lucky.

For children like Hazel-Grace and Augustus, children who develop cancerous tumours in the womb already, in the first few years of life, or a little later, is something totally incomprehensible: how can such a thing happen at such a young age, or before even being born! What have they done to deserve this? This is not intelligible, not acceptable, simply not possible. Naturally, it can only be a ‘fault in our stars’, a fault in their stars. It cannot be anything else. It must be some kind of problem at the source, at the mystical, magical source of the life of these poor, unfortunate, afflicted children.

This may be a way to help us accept the situation and just make the best of it for as long as possible, with strength, compassion and courage, but it is a lie. A romantic and poetic lie, but a lie nonetheless. The truth is that cancer is never, has never been, and never will be a ‘fault in our stars’, a stroke of bad luck, an unfortunate turn of events. Whether it develops while we are still in our mother’s womb, when we are three, five, ten, thirteen, eighteen, thirty three, forty two or sixty nine, it is never due to chance.

For cancer to develop two conditions must be fulfilled: there needs to occur an initial structural damage at the cellular level, and there needs to be a biochemical/immune environment that permits the subsequent development and evolution of the cancer cells. Without these, cancer cannot develop. Under optimal biochemical and immunological conditions and function, cancer cells that do appear for whatever reason are immediately destroyed, cleaned out and replaced by healthy cells.

For unborn children, there is little doubt to be had that cancer can primarily be due to the mother’s having been exposed either prior to or during pregnancy to carcinogenic agents: respiratory poisons, hormone disruptors or mutagenic substances. The embryo is so fragile and so vulnerable, especially to respiratory poisons because of its propensity towards glucose fermentation, that minute amounts otherwise unnoticeable by the mother can be enough to cause the formation and growth of what will turn out to be large tumours by the time the baby is born, often the case for retinoblastoma as in the case of Augustus’ closest friend, and, as it happens, in the case of the daughter of a close friend of mine, the baby is usually born with at least one of the eyes’ optic nerve covered in cancerous tumours, prompting the removal of the eye and nerve as soon as this is identified.

Throughout childhood, the less mature child is always more vulnerable and fragile than the more mature individual, and this is always thus in relation to the maturity of the cells, tissues and organs of the developing child. Some cells and tissues are more vulnerable, like the brain, for example. But all immature cells are significantly more vulnerable than their mature counterparts. And knowing that all immature cells tend to higher fermentation rates, shouldn’t it be considered the most reasonable approach to completely restrict sugars and carbohydrates at least until the child has reached the first stage in maturity at about 7 years of age, feeding them mostly fat in natural forms and chlorophyl-rich vegetables, keeping glucose and insulin as low as possible and thus ensuring that any damaged (pre-cancerous) cell relying on glucose fermentation will silently perish and be swept out before even the smallest cluster of such cancer-promoting cells has formed, let alone a full blown tumour, the smallest of which contain billions of cancer cells?

Shouldn’t it be considered only reasonable to just stop behaving so ridiculously irresponsibly towards ourselves, towards our children, towards our environment: the air, the soils, the lakes and rivers, the seas and oceans? To stop dumping so much chemical rubbish in our bodies, in those of our children and in the world all around us? It seems to obvious yet for some reason it isn’t to most people, and certainly not to politicians and policy makers worldwide who seem to be precisely those least apt to make those decisions and formulate those policies intended to minimise damage and disease by restricting the production and release of poisons in air, water, soil and food.

At least, at the very least, we have to stop feeding ourselves and our children foodstuffs that are devoid of nutrients and laden with sugar, chemicals and other man-made, denatured molecules like trans-fats and high fructose corn syrup. At the very least, we have to start simply drinking plain, pure and clean water: not juice, not milk, not soda or other sugary drinks, just water. We have to start eating fresh whole foods, those that don’t have labels, that are not wrapped in plastic, and that do not come in box. And we have to just stop using chemicals in our showers, kitchens, in our homes and in our gardens.

It’s so simple, but I so often feel stupid saying and writing things of this sort just because is it so simple and obvious. And yet, it’s amazing how rarely I encounter people who also see these principles as obvious. If you don’t yet, please think about it for a while, and ask yourself this: what are, if not these, the most basic steps to take to ensure our own health and that of our children, those growing up around us and in our care, those curled up in the warm and cosy space of their mother’s womb, and those yet unborn and not yet conceived either in thought or in actuality, those little stars shining silently in the night sky?

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On the origin of cancer cells – part 2

Fifty years of intense research had passed from the year he received his doctorate in chemistry in 1906 to the year when On the Origin of Cancer Cells was published in 1956. The uniquely exceptional scientist that was Professor Otto Warburg was nominated for the Nobel Prize by his scientific peers a total of 46 times between 1923 and 1931, with 13 of these nominations in that last year. And in 1931, he was awarded the Nobel Prize for his seminal work on the essential role of iron in the biochemistry of cellular respiration published in 1928, and more generally for his work on the aerobic and anaerobic metabolic processes in cells. He was also, in that year, made director of the Kaiser Wilhelm Institute for Cell Physiology in Berlin (renamed Max Planck Society in 1948), and he maintained not only his post but also his scientific activity until his death in 1970 at the age of 86.

otto-warburg-old-highresfaceshot

In fact, in 1969, just months before his passing, he published with one of his long-standing collaborators Dean Burk who translated the text (as he did for the 1956 paper), a revised and additionally prefaced version of the lecture he gave at the meeting of Novel Laureates at Lake Constance, Germany, in 1966 entitled The Prime Cause and Prevention of Cancer. The tone of this lecture, both for the first part of 1966 and the second of 1969, transpires frustration and even anger at the general lack of notice and acceptance of the crucial elements of the physiology of cancer cells that he had studied, understood, elucidated and clearly described in his publications over the course of more than 60 years of research.

Attempting to formulate a well-rounded and balanced explanation would require a lot of time and effort, not to mention a lot more words. But it is evident that then as now, financial interests have generally always been among the strongest driving forces both in research and in developing applications based on the understanding derived from this research. Hence, it is more than clear that eliminating the use of chemicals in all agricultural and industrial processes, stopping the consumption of simple and starchy carbohydrates and refined foods, and supplementing with iron, niacinamide and enzymes in general like Warburg recommended and did as a means to prevent and treat cancer is not only not at all lucrative, but it is highly financially detrimental to all chemical-based agricultural and industrial activities. I believe this is a most important part of the explanation, as it is for so many things.

What Warburg understood

Warburg had slowly, carefully, cautiously, diligently, painstakingly carried out experiment after experiment, trial after trial, studying every last detail of every aspect of the experimental process. He explained the cell’s most vital function, that of respiration, using oxygen to burn glucose or fats and produce energy, with a particular focus on the critical role of iron as a ‘respiratory enzyme’ carrying the oxygen molecule. He explained that the glucose molecule was ‘fermented’ (that it underwent glycolysis) in the cytosol of the cell, split into pyruvate molecules and fermented to lactic acid, and that this produced a small amount of adenosine triphosphate (ATP) without the need or use of oxygen. This process is termed anaerobic fermentation.

He explained that this process could either stop there, or be extended further by the pyruvate being taken up into mitochondria of the cell, and with the use of much oxygen, almost magically produce a lot more ATP without needing any additional glucose, but going through a series of steps and transformations relying primarily on clever recycling and reusing mechanisms of the niacin (B3) based molecule NAD (which stands for Nicotinamide Adenine Dinucleotide) within the mitochondria.

The ATP-generating process taking place inside the mitochondria was eventually described in detail by one of Warburg’s students, Krebs, who was awarded a Nobel Prize in 1953, and to which his name was given as the Krebs cycle also known as the citric acid cycle, as everyone who has studied some biology has heard (even if you never quite understood was this stuff was all about). Note that the Krebs cycle produces only 2 molecules of ATP, just as glycolysis does, and that it is what is called the electron transport chain, also taking place inside the mitochondria and using plenty of oxygen, that produces the bulk of the ATP with a potential of an additional 34 molecules, using products of the Krebs cycle, and in particular the 10 molecules of NADH.

Warburg was motivated to understand at the most fundamental level what was the difference between healthy cells and cancer cells. Naturally, as cancer was already a devastating disease in the 1930’s, he wasn’t the only scientist working and leading researchers in the study of the mysteries of cancer. He was, however, one of the most talented, dedicated and productive, together with the group of scientists he led at the Kaiser Wilhelm Institute and those with whom he collaborated.

The first major step was made in showing that tumours fermented glucose much more intensely than healthy tissues that normally hardly do so at all. This fact—that tumours ferment a lot more glucose than healthy mature tissues even in the presence of oxygen—is known as the Warburg Effect and is universally studied in physiology, medicine and oncology (cancer-ology). This fact is so fundamental to cancer metabolism as well as cancer research that it is the basis of the PET scan imaging technique in which radioactively labelled glucose is used to make detailed images of active tumours and their tendrils in our tissues. The reason why it works is that cancer cells take up glucose from the bloodstream far more efficiently than normal cells.

What is unfortunate but not surprising given how myopic scientists and we all in general tend to be, is that this has been consistently overlooked as being a critical aspect of the genesis of cancer, as Warburg’s research implied, and instead has been interpreted as a consequence of the dysfunctional cellular metabolism of these mutated cells that is unrelated to the actual development of the cancer.

This is pretty absurd. After all, if cancer cells derive a substantial fraction of their energy from fermenting sugar, wouldn’t the absence of sufficient glucose naturally halt the growth and proliferation, and thus the development of tumours? And even more fundamentally, because glucose can only be transported inside the cell by the action of insulin, and it is, in fact, to insulin—not glucose per se—that cancer cells are incredibly more sensitive than healthy cells, wouldn’t an important drop in circulating insulin levels be detrimental or even lethal to cancer cells? Of course it would! They would be starved of the only fuel they can use, and as a consequence, eventually become incapable of sustaining their activity.

How was this measured?

The way it was done was to measure oxygen consumption and lactic acid production either with plenty of oxygen or without any, for tumours and different tissues under physiological conditions of pH and temperature. This is the perfect trick because fermentation outside the mitochondria does not require any oxygen, whereas energy production by glucose oxidation inside the mitochondria depends entirely on the presence of ample amounts of oxygen, In fact, even a minute drop in oxygen concentration will negatively affect mitochondrial ATP production. Cancer cells don’t care much if there is oxygen or not: they don’t use much and therefore don’t depend on it. They ferment glucose anaerobically no matter what because this is the only way they can generate enough energy to survive.

It was understood a number of years later that tumours are rather heterogenous both in terms of the types of cells and tissues they are derived from, and in the concentration of cancer cells: tumours can grow extremely fast or extremely slowly; they can have a large proportion of cancer cells in relation to normal cells or a small one; and since different specialised tissues require different conditions and function differently, it is an obvious consequence that tumours developing in different tissues will have different characteristics.

Hence, the next step necessitated the isolation of cancer cells in order to avoid the problem of dealing with heterogeneous mixtures of cancer and healthy cells cohabiting in a solid tumour. It was this that Warburg presented in the 1956 paper, and what a difference this would make! These are his opening paragraphs:

Our principal experimental object for the measurement of the metabolism of cancer cells is today no longer the tumour but the ascites cancer cells living free in the abdominal cavity, which are almost pure cultures of cancer cells with which one can work quantitatively as in chemical analysis. Formerly, it could be said of tumours, with their varying cancer cell content, that they ferret more strongly the more cancer cells they contain, but today we can determine the absolute fermentation values of the cancer cells and find such high values that we come very close to the fermentation values of wildly proliferating Torula yeasts.

What was formerly only qualitative has now become quantitative. What was formerly only probable has now become certain. The ear in which the fermentation of cancer cells or its importance could be disputed is over, and no one today can doubt that we understand the origin of cancer cells if we know how their large fermentation originates, or, to express it more fully, if we know how the damaged respiration and the excessive fermentation of the cancer cells originate.

This was the programme that in the end led to the discovery that cancer cells produced 2-3 times (that’s 200-300%) more lactic acid than the most solid tumours. This meant that even those most solid tumours must have been composed of only about 1/3 active cancer cells, and thus 2/3 normal and inactive cancer cells.

This is necessary because cancer cells cannot do the things needed for the tumour to survive and grow, like making new blood vessels for example; only healthy cells can carry out such specialised activities. The wildly fermenting and proliferating cancer cells are dependent on healthy cells in the tissue where they are growing in order to survive. This makes good sense given that cancer cells gradually devolve, generation after generation, losing their function, their specialisation and their differentiated nature, and eventually cannot do much of anything but ferment glucose and replicate. For this reason, they rely on the healthy cells to maintain a viable environment for them.

Oxygen is crucial

Recall a key observation that was made in comparing the metabolic activity of cancer cells to normal cells: as the cell transitions from functioning normally and deriving virtually 100% of its energy needs by burning glucose (or fat) with oxygen inside the mitochondria, towards the defective cancerous cellular metabolism characterised by fermenting glucose without oxygen outside the mitochondria, they derive progressively more energy from fermentation and less from oxidation, independently of the amount of oxygen available.

You see, if oxygen in the cell drops, then ATP concentration drops because the mitochondria need the oxygen to make ATP. Immediately, fermentation outside the mitochondria will begin or increase in order to make up the energy deficit. This is normal and happens in all healthy cells whenever this situation occurs. However, the drop in available oxygen will also trigger heart rate and breathing to increase in order to make more available. This will very quickly correct the problem, allowing the cell to stop fermenting and return to the much preferred condition of generating ATP though oxidation in the little power plants that are the mitochondria. Once again, this is perfectly normal and happens in healthy, well-functioning cells every time we exercise.

Those cultured cells with which they were working did not have the support of the entire organism that we have, exquisitely fine tuned and orchestrated by countless specialised hormones, sensor cells, worker enzymes, etc., to react instantly to any kind of chance of condition. As oxygen concentration dropped, fermentation increased. But if oxygen levels weren’t replenished quickly enough, the damage to cellular respiration was found to be irreversible. Now, fermentation continued no matter if oxygen levels were raised to saturation following the period of hypoxia.

Not only did fermentation continue under oxygen saturation, but it increased over time. This is what was meant by irreversible in terms of the damage to respiration sustained by the period of deficient oxygen levels, and this is what showed very clearly how a cell can transition and devolve from normal and healthy to cancerous. The same observations were made irrespective of the means that were used to damage respiration: arsenic, urethane, hydrogen sulphide and its derivatives, hydrocyanic acid, methylcholanthrene and whatever else, whether oxygen was deficient or prevented from reaching the cell by a respiratory poison, the result was irreversible damage that always eventually resulted in cancer cells if the damage wasn’t too severe, because otherwise the cell would not survive at all.

The unavoidable consequence of this was immediately understood: it is the cumulative effect of chronic exposure to small amounts of carcinogenic respiratory poisons or low-oxygen that causes and leads to cancer within our tissues. Very unfortunately for us, the number, spread and quantity of such carcinogens grows with each passing day. Is it any wonder then, that cancer rates are soaring? That it is a modern plague in our highly industrialised, pesti-cised, herbi-cised, fungus-ised and globally chemi-cised countries?

Measuring cancer cell metabolism

Quantitative measures of cellular activity and metabolism of ascites cancer cells were done keeping the cells in their natural medium, ascites serum, that was ‘adjusted’ physiologically once they were removed from the abdominal cavity. Adjusted how? By adding glucose to feed them, but also bicarbonate to neutralise the lactic acid, because the fermentation rate was so strong that without the bicarbonate the pH would drop too quickly and too drastically, causing fermentation to be brought to a standstill and soon after the cells to die.

Under physiological conditions of pH and temperature, in units of cubic mm for 1 mg of tissue (dry weight) per hour at 38 C, they found the following:

  • Oxygen consumption: 5 to 10,
  • Lactic acid production with oxygen saturation: 25 to 35, and
  • Lactic acid production without oxygen: 50 to 70.

Warburg and colleagues estimated that in anaerobic glucose fermentation, one mole of ATP was produced for every one mole of lactic acid. In contrast, even though the exact details were not yet known, measurements indicated that in cellular respiration, 7 moles of ATP could be produced for every mole of oxygen that was consumed. Based on these estimates, they compared ATP production form fermentation and oxidation in different types of cells.

Healthy liver and kidney cells showed identical metabolic values, consuming 15 cubic mm of oxygen per mg per hour, and in the absence of it, producing only 1 cubic mm of lactic acid. This means these cells were very poor at fermenting glucose; they could basically only derive energy from oxidation within the mitochondria. And this was made even more apparent by comparing, as they did, the amount of ATP that can be derived from fermentation or from oxidation. Using the 1:1 ratio of lactic acid to ATP under fermentation, and the 1:7 ratio of oxygen to ATP under oxidation, they found that these healthy liver and kidney cells could derive 105 (that’s 15 x 7) moles of ATP from oxidation versus only 1 from fermentation. As a fraction of the total, this is 105/106 or 99.1% from the normal mechanism reliant on the Krebs cycle and electron transport chain inside the mitochondria.

Next they looked at very young embryonic cells and found equal oxygen consumption of 15 cubic mm, but with a significantly greater—25 times greater—production of lactic acid when oxygen supply was cut. What this means is that these embryonic cells were much better adapted to surviving in anaerobic conditions without oxygen. This is quite natural given that the less evolved the cell, the more primitive and less specialised or differentiated, and therefore the closer to simpler cellular forms like yeasts. Doing the same as above in translating this metabolic function to compare the amount of ATP derived from either anaerobic or aerobic usage of glucose, we find that the same amount of 105 cubic mm of ATP from respiration, but in this case 25 moles of ATP from fermentation. And so, in this case the fraction is 105/130 or 80.8%, compared to the above 99.1% in normal liver and kidney cells.

The difference between these numbers and those calculated for the ascites cancer cells was large: they consumed less than half the oxygen, 7 cubic mm, but produced a whopping 60 cubic mm of lactic acid. That was 60 times more than the healthy mature liver/kidney cells! Here, ATP derived from respiration was therefore 49 (7 x 7) compared to 60 from fermentation. Hence, the fraction of the total that could be derived from oxidation was a mere 49/109 or 45%, implying that more than half the energy requirements could be derived from fermentation. This is how these quantitative measurements on the metabolism of healthy and cancer cells were done, and the result was indeed a remarkable finding.

What these results explained

So many things were understood or clarified through his efforts across these five long decades of intense research, and now with these latest results we understood different cell types have different propensity to become cancerous based solely on the cell’s inherent propensity towards fermentation: the higher the amount of ATP that could be derived from anaerobic fermentation, the easier it would be for the cell to become cancerous, and also the faster the tumour would grow.

The unfortunate but unavoidable implication is that embryos whose cells are all immature and therefore more primitive and naturally prone to greater fermentation, are the most susceptible to sustain damage to respiration whether from periods of low oxygen (think asthmatic mothers) or from exposure to respiratory poisons (think anything from pesticides, herbicides, food preservatives, to just supermarket household ‘cleaning’ and skin ‘care’ products, synthetic perfumes or substances they contain, and on and on…). Here again we can ask: is it any wonder that infantile cancer rates are also on a sharp rise?

We understand, for exactly the same reasoning, why cancer tumours in different tissues grow at different rates under the same physiological conditions, and easily explain why the increase in fermentation is gradual, requiring many cell divisions after the initial injury. As we know very well, it typically takes decades for adults to develop large cancer tumours that cause enough of an effect to get us to the hospital before it is diagnosed as such. Also, we know that tumours in or near the brain can develop and grow very quickly—within a year or two—whereas for the prostate they typically take an entire lifetime, sometimes completely unbeknownst to the host whose quality of life is not affected noticeably.

It was also understood why radiation therapy was generally effective at reducing the size of solid tumours by killing those already weakened and energy deficient cancer cells through a final blow to their injured and struggling mitochondria. By the same token, however, radiation will also always damage mitochondria of healthy cells, and thus set them on their way towards the process of devolution into dysfunctional fermenting cancer cells that the injury to respiration brings about.

And imagine this: 52 years following the publication of this landmark paper and a whole three quarters of a century after Warburg’s discovery of the fermentation of tumour cells even in the presence of oxygen, was published in the journal Nature a paper entitled The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. In this paper the authors describe how they were able to manipulate the expression of this enzyme in cancer cells, and doing so, decrease fermentation while increasing oxidation of glucose.

This enzyme, pyruvate kinase, is expressed in mammals in four different flavours (isoforms): L is expressed in liver cells, R in red blood cells, M1 is by far the most dominant and is expressed in most adult tissues, and M2, a variant of M1, is expressed during embryonic development. As it turns out, and as reported by two other groups of researchers in 2005 (refs 2 and 7 in the 2008 Nature paper), tumour tissues exclusively express the embryonic M2 form of pyruvate kinase.

Expressing these results as simply as we can, the situation appears to be as follows: once a glucose molecule enters the cell through one of the insulin-mediated entry ports, it is in the cytosol. There, through a series of 10 enzyme-mediated steps, it is split in two molecules of pyruvate. This requires 2 ATP but produces 4 ATP molecules; hence there is a net production of 2 ATP. At this stage pyruvate can either be converted to lactate which then turns to lactic acid, or to acetyl-CoA which is then transported to the mitochondria to enter the Krebs cycle and the electron transport chain. This transformation of pyruvate is performed by the enzyme that is the subject of these scientists’ investigation, pyruvate kinase. It would seem that the M1 form, the one that is active in healthy cells, takes pyruvate into acetyl-CoA and into the mitochondria, whereas the M2 form, the one that is expressed in embryos and cancer cells, takes it into lactic acid.

By some clever genetic manipulation, working with tumours in rats, they were able to switch off M2 expression and switch on M1 expression in cancer cells, and measured a decrease in lactic acid production and an increase in oxygen consumption that was associated with ATP production in the mitochondria through oxidative phosphorylation. This is the remarkable result that made the paper worthy of a publication in Nature magazine. And it is indeed amazing! This is why they write in the first paragraph that based on their research, the defect is not with the mitochondria as Warburg thought, but rather it is with the expression of the enzyme pyruvate kinase that goes from the healthy M1 to the embryonic M2 form. Why or how this happens is unknown.

This is indeed very encouraging! Just the idea of being able to force the expression of the healthy M1 and suppress the cancerous M2 form of pyruvate kinase is really amazing and has very important potential implications for cancer prevention and treatment. And this even if we don’t really yet know why or how it happens. But tell me, have you ever heard of this more than critically important result in cancer research on the news? Do you think your doctor has? Or his oncologist colleagues that cut, poison and burn cancer patients day in and day out?

Our basic cancer-fighting strategy?

What can we gather from this work that can help us not just understand Warburg’s research and his remarkable contribution to humanity though it, but also avoid cancer in this world where more than 1/3 of people currently succumb to it and where cancer rates keep rising every year?

Naturally, we want to minimise as much as possible our exposure to all manufactured chemicals, especially those confirmed as carcinogenic. We are all exposed to a greater or lesser extent through our being immersed in the environment in which we live, but we can go a long way by eating the cleanest, most natural and unprocessed food possible, drinking the cleanest water possible, using only natural cleaning and skin care products, and using regular or daily detoxification strategies such as taking sodium bicarbonate and magnesium chloride baths one to three times a week, drinking psyllium husks in water to cleanse the colon, and supplementing with iodine, chlorella and spirulina daily to flush out chlorine, fluorine, bromine and heavy metals like lead, mercury and arsenic on a continuous basis. These are, in a way, the simplest and easiest preventative measures we can take to reduce as much as we can our exposure to external sources of potentially carcinogenic and otherwise dangerous substances, as well as do what we can to flush them out to prevent accumulation in our tissues.

In consideration of the two fundamental characteristics of cancer cells—that they rely on glucose fermentation, and that they live and thrive in a milieu that his highly acidic and deprived of oxygen—it is just common sense to conclude that doing the opposite of what they need and prefer would be a good strategy. Doing the opposite means minimising glucose availability and especially insulin that is ultimately the agent responsible for transporting the glucose into the cell; remember that this is why cancer cells typically have 10 times the number of insulin receptors on their surface than normal cells. Doing the opposite also means preventing the accumulation of metabolic acids in their subsequent storage in tissues, preventing latent tissue acidosis, and ensuring a plentiful oxygen supply from a highly alkalising drinks, foods and lifestyle.

The first can be achieved by eliminating all simple and starchy carbohydrates, refined or not. Blood glucose levels will drop, and insulin levels will follow suit. This will shift the metabolism towards relying on fat as the primary source of cellular fuel throughout the day and night, day after day. The cool thing is that healthy cells function much more efficiently by burning fatty acids in the sense that they derive a lot more energy than they can do from burning glucose, even if the later is easier and enzymatically simpler: it is, after all, common to all living organisms, including the most primitive. The important difference is that all evolved and highly specialised animal cells can use fat, whereas primitive or devolved cancer cells simply cannot.

The second can be achieved by keeping the body hydrated and alkaline by drinking and eating to promote the alkalisation of the digestive tract, the blood, the other fluids of the body, and thus the tissues throughout: alkaline water and pressed lemon water, highly alkaline and alkalising freshly cold pressed green vegetables both juiced and whole, and magnesium chloride and sodium bicarbonate baths. Eating plenty of unrefined sea salt is also of the utmost importance in this. These are among the most important and effective means to first pull out and eliminate stored acids from the tissues and body, and then maintain alkalinity.

The only caveat is that digestion of concentrated protein in animal food, for example, require an acidic stomach for complete breakdown and digestion. Therefore,we should not combine alkalising water, lemon water or green juice when eating protein because this will cause poor digestion and absorption. Also, because protein is very important but also highly acid-forming, it is essential to not have excessive amounts, especially in a single serving, because this will cause excessive acidification and toxicity. Restrict your servings of animal protein to about 30-50 grams per serving, and try to restrict that to one main meal in the latter part of the day (afternoon or evening).

Pretty simple, aren’t they, these two strategies that we can draw from what we have learnt about cancer up to now. We will further explore cancer metabolism, prevention and treatment in the future, looking at methods that have been and continue to be successfully used to treat cancer patients and bring them back to health, as well as important nutrients and supplements with powerful cancer-fighting and health-promoting properties. But the fact is that these two basic points that address the most fundamental characteristics of cancer cells to ensure, on the one hand, that those that do emerge one way or another cannot sustain themselves or grow due to the lack of enough glucose and insulin for their needs, and on the other, cannot readily develop from being pushed towards fermentation because the environment of the body is everywhere alkaline and oxygen rich, are probably the most effective and important measures to grasp and apply in order to remain optimally healthy and cancer-free for as long as we are alive.

In closing

Before closing I want to briefly highlight that the vast majority of effective natural cancer healing treatments are based to a greater or lesser extent on the understanding of cancer as I have presented it in this and the previous article on the subject. However, there is a truly wide range of successful treatments that are used out there in various specialised cancer treatment centres. One important point to make in regards to the consumption of simple sugars from sweet root vegetables such as carrots and beets or fruit is that several treatment protocols include these and in sometimes large quantities still with great success in overcoming cancers of various kinds. This shows us that there is definitely more to preventing and treating cancer than just eliminating simple sugars.

There is lot of tremendously interesting material to explore about cancer, a disease that has been an important cause of suffering for at least a century. A lot of this exploration will be of historical research, experiments and discoveries that either have escaped the attention of the masses and medical establishment, or been actively suppressed by various agencies and individuals intent on nurturing as substantial population of ailing people for the purpose of profiting from the treatments they would require.

As awful as this may seem, it is unfortunately the sad truth. And even more unfortunately, this is not only historical as in the case of this well documented 1921 action plan by the US government, FDA and AMA for an influenza vaccination campaign to quickly and effectively spread disease across the country and greatly stimulate the need for medical attention and case as a means to generate profits from the associated expenses, but this continues to this day. The essential conclusion to draw from this is that it is we who must care for ourselves, our children, our family members, and our friends. And to do this, it is again we who must first learn and then teach our children and each other how to best do it. This is what I strive to do and what I strive to share with you.

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On the origin of cancer cells – part 1

On February 24 1956 was published in the journal Science a remarkable and exceptional paper by an equally remarkable and exceptional scientist. The paper was entitled On the Origin of Cancer Cells, and the author was the winner of the 1931 Nobel prize for Physiology or Medicine, Professor Otto Warburg.

otto-warburg-old-highresfaceshot

Professor Otto Heinrich Warburg (1883-1970)

After more than 50 years of research on cellular respiration, metabolism and physiology, Warburg had identified, understood, demonstrated and now explained the mechanisms by which cancer cells develop, survive, spread and proliferate, and what, at the most fundamental level, distinguishes them from normal cells.

It is my intention to relate the essence of these results, together with the necessary background, as clearly as it is possible for me to do with the hope that you will remember it well. This is without any doubt one of the most important and far-reaching results of medical science in its entirety. Such is the importance of this work, that it may well be the most important bit of medical science I will ever write about and that you will ever read about. But although this is so, it can be stated in a single sentence.

The truth about the origin of cancer is that despite the numerous carcinogenic agents, those identified as such and those still unknown, and despite the numberless forms and tissues in which cancer can manifest itself, there is only one fundamental cause of cancer at the cellular level: injury to respiration by damage to mitochondria.

Biological energy

The mitochondria, independent micro-organisms with their own metabolic and reproductive systems living symbiotically with the other organelles inside the cell, could be considered as the most important of the organelles because it is the mitochondria that normally produce the energy (in the form of adenosine triphosphate or ATP) on which each cell, and therefore also the entire organism, rely for function and survival.

Each cell must produce the energy it needs to sustain its activity and maintain its structure, and each cell cares only about itself: it knows only what it must do and what it needs in order to keep itself alive in the best possible condition and health that it can manage through continual adaptation. The way it knows anything else outside of itself is by sensing its environment, its immediate surroundings, through the various sensors (biochemical receptors) and doorways (ionic channels) in its walls (the cell’s outer double-layered membrane).

Cells can produce energy using glucose (from carbohydrates), amino acids (from protein) or fatty acids (from fat). By far the most effective way to do it is through burning fatty acids. This produces the most energy and no acidic byproducts. This is therefore a normal cell’s preferred fuel.

There are two intervening factors, however, that make it rather rare for humans to function primarily on energy derived from fat. And although this is true today, it wasn’t for the bulk of our evolutionary history during which all species of homo must have derived most, and probably often even all, of their energy from fat. The first and most important of these factors is that today, we tend to get most of our calories from carbohydrates.

Because it is easier for cells to breakdown and use the much smaller and simpler glucose molecules than it is to use the longer and more complex fatty acids, while there is enough glucose in the bloodstream, it will always be used preferentially, and eventually almost exclusively, as the cells grow insulin-resistant and become unable to use fatty acids almost completely. In such a metabolic state, because protein can relatively easily be converted into glucose, this is what the body does when it runs out of glucose, because, from the lack of practice, it cannot access the fat stores. Therefore, due to insulin resistance, fat just keeps accumulating, stock piled in ever larger and distended fat cells throughout the body, and never used to make energy for the now struggling, energy-starved cells.

The second factor is strictly physiological, and relates to the fact that it takes longer to oxidise fat than to oxidise glucose, and even for glucose, it takes about 100 times longer to oxidise inside the mitochondria than it does to process it anaerobically (without oxygen) in the protoplasm, the general space within the cell, outside the mitochondria. For this reason, in circumstances where the cell needs ATP quickly (in lifting weights or sprinting, for example), it will need to use this super fast energy production mechanism in addition to the slower oxidation in the mitochondria, with proportions that depends on the energy demand.

All ATP production using glucose begins with its breakdown into something called pyruvate. This is called glycolysis (or substrate level phosphorylation). It takes place whether there is oxygen available or not, and does not involve the mitochondria because it takes place in the protoplasm. Glycolysis involves 10 steps each of which requires the action of specialised worker proteins (respiratory enzymes). From this process the cell derives two molecules of ATP. Pyruvate is the main product, but the process also leads to the production of lactic acid and hydrogen ions.

At this point, the pyruvate can be carried to the mitochondria where through a much lengthier and vastly different process (oxidative phosphorylation), which in this case relies on an ample supply of oxygen, the mitochondria can produce up to an additional 34 ATP molecules (this is the case in aerobic yeasts), for a total of 36 counting the first two from glycolysis.

In practice, factoring in some metabolic inefficiencies in the process, the result is probably somewhere around 28-30 molecules of ATP for our cells. This is nonetheless a lot of energy—15 times more than from glycolysis alone—that can be derived from a single molecule of glucose. Bear in mind, however, that gram for gram, fat can produce six times more energy than glucose, raising the total to around 200 molecules of ATP, and this without producing acidic byproducts.

Aside on the use of words and names as symbols

Before going any further, I want to bring your attention to something important, generally unrecognised, but essential to our understanding and perception of the world and everything we come into contact with. It is language, complex language, symbolic language, that allowed a small subgroup of Homo Sapiens to first distinguish themselves from all other animals and also from all other species of Homo, and then spread across the continents and come to dominate almost every ecosystem on the planet.

The more language is refined and the more thorough is its mastery, the more complex cognitive processes become and the more subtleties of understanding can be both expressed and discerned. There is a major problem, however, that comes about in every language-using person, and this is that the symbol used to refer to something, the word, is unconsciously taken to be the same as the object to which it refers. Furthermore, not only is the object treated as an entity on its own, a thing that does not depend on anything else to be what it is (which, of course, it does), but the word also becomes a thing unrelated to other words that are different in appearance and sound.

This is a serious problem for understanding complex processes. And it is particularly relevant in this discussion here. We must remember that even if we are talking about all sorts of different things like glucose, amino acids, fats, pyruvate, enzymes, mitochondria, organelles, and on and on, that these are all words, symbols that we use to identify molecules and little beings like mitochondria that do not possess language, and further, that do not care at all what we call them.

It is best to view this whole business of processes at the cellular level as a ceaseless dance where atoms mostly of carbon, hydrogen, oxygen and nitrogen with a few others here and there, combine into molecules that are manipulated by proteins into other molecules, sometimes simpler and sometimes more complex, the change sometimes being unidirectional and sometimes a reversible state change going back and forth, everything depending everywhere on the characteristics of the environment, the stage, in which this dance is taking place. And that all of this takes place totally unaffected and independently from any of the names we have for any of its characters and dancers.

So don’t be fooled by the words and names in thinking that because the names are so different they are referring to inherently different things. This is not so. Words and names are just words and names. We use them to express ourselves, but must not be moved to believe that they are referring to entities having a life of their own, interacting in a world of things where every thing bounces against every other thing. This is just wrong, and it is highly misleading: clearly misleading in the realm of cellular biology, which is our immediate concern in this article, but also misleading in our everyday, which should definitely be of concern.

Back to cellular respiration

Cellular respiration (oxidation in the mitochondria) requires oxygen. If for any reason there is not enough, the cell uses a backup method to sustain its energy needs. This happens when the energy demand is so great that the cell cannot wait for the mitochondria to produce the additional ATP (as mentioned above under extreme exertion), but also if there is simply a lack of oxygen for any other reason, whether it is acute, like from exposure to a large enough amount of a respiratory (mitochondrial) poison or during an asthma attack, or chronic, like when we spend our days in an office building with recycled air where levels of oxygen are lower and carbon dioxide higher than they should ideally be, but not quite enough to become a problem noticeable by a critical number of people. In such cases, instead of being brought to the mitochondria, the pyruvate can be used as the oxidative agent by the respiratory enzymes to ferment the lactic acid, and recondition the NAD so that it can engage again in the breakdown of another molecule of glucose into pyruvate. (We’ll come back to the details of this another time.)

Essential to remember is that for a normal cell this is the solution of last resort when there is not enough oxygen, and that animal tissues suffer serious damage when deprived of oxygen for an extended time, where ‘extended’ here is on the timescale of cellular processes, which for us is very short—on the order of minutes.

Anyone who has done all out sprints with high resistance on a bike, or bench pressed a heavy weight to muscular failure, knows the feeling associated with the muscles being unable to respond to the load. This is because the cells are starved of oxygen and overloaded with acid. Under extreme exertion, lactic acid fermentation for ATP production dominates from about 10 to 30 seconds, and muscular failure follows within 30 to 60 seconds.

Struggling to survive

As we’ve seen, there are two major differences between these processes of using glucose for energy production. The first is that for one molecule of glucose, complete oxidation produces around thirty molecules of ATP, whereas glycolysis or fermentation produces only two. The second is that oxidation occurs inside the mitochondria, whereas fermentation, sustained by respiration enzymes, takes place outside the mitochondria. Therefore, it is both the quantity and quality of the energy that is degraded.

Also as we’ve seen, a normal cell under normal circumstances sustains itself—both in function and structure—by relying on the energy produced by the mitochondria, whether by oxidation of glucose (pyruvate) or fatty acids, and only ever use fermentation for energy balance adjustments in exceptional circumstances. If, however, for any reason at all, even a small number of the mitochondria in the cell get damaged, a serious problem arises because the injury makes the cell incapable of producing the energy it needs for proper function, maintenance and repair.

If the damage is severe, the cell will die, and will, if things are running relatively smoothly, be broken down, cleaned up, excreted and replaced by a new one that will take its place. If the damage to the mitochondria is not so severe, the cell will not die, but will be crippled in its energy-producing capacity, the mitochondria will not be able to produce all of the ATP the cell needs, and this will force it to use fermentation to top up its energy requirements.

Unfortunately, the injury to the mitochondria’s genetic code will not only be passed down from the damaged parent to the next generation, but will lead to an irreversible degradation of mitochondrial function with each transcription and reproduction into each successive generation of these vital organelles. With each generation, the mitochondrial function is degraded further and the energy deficit grows.

As a consequence, the growing energy deficit is compensated by increasing ATP production from fermentation. But the energy from fermentation is not just less plentiful, it is also of a much lesser quality compared to that resulting from proper aerobic respiration involving the mitochondria, and it simply cannot maintain the structure and function of the cell. Thus, the cell degrades. Everything about the cell degrades as it struggles for survival.

The evolution in the ratio of energy produced by respiration to that produced by fermentation, initiated by the damage to the mitochondria and driven by the cell’s striving to maintain energy balance, is in fact a devolution from a finely tuned energy production system of a highly refined and specialised cellular structure and function, to a primitive energy producing mechanism and a coarse and severely degraded cellular structure and function akin to what we see in yeasts and fungi.

The birth of a cancer cell

Degradation and devolution continue until fermentation energy is enough to fully compensate the loss of respiration. It is at this point that we witness the emergence of a cancer cell. And it is now a perfectly functional and healthy cancer cell that has lost enough of its original characteristics, both structural and functional, to begin a programme of its own, intended to increase as much as possible survival probability in its new and partially self-generated environment that should ideally be high in glucose—as high as possible, low in oxygen—this is preferred but not critical, and highly acidic—cellular pH as low as 6 or even less and extracellular pH potentially significantly lower.

Although these terms, birth and emergence, are powerful and very useful in conveying a vivid imagery of a developing process that eventually reaches and overcomes a critical threshold as it is the case here, it is not really a birth or an emergence as much as it is a metamorphosis, gradual and typically very slow, taking place over decades if not over most of a person’s lifetime, with a continual and intimate dependence on the biochemical makeup of the environment surrounding the cell, and surrounding each and every cell throughout the body, from hair, scalp and skin, to fingers, fingernails, toes and toenails, from mouth to colon, from brain to liver, from breast to uterus, from throat to prostate, and from and to everything else that constitutes the entire human organism inside and out.

Over this long struggle for survival, because this is truly what it is, the cell is at first forced to generate supplemental energy from fermentation to make up the small difference that the slightly damaged mitochondria cannot. This increases the level of acid inside the cell. Because every enzyme-mediated biochemical process that takes place—and that indeed has to take place—is sensitively pH-dependent, all are instantaneously affected negatively by this acidification and drop in pH.

Moreover, increased acid translates directly into lack of oxygen, which further stresses the mitochondria, making their oxidation of glucose and fatty acids more difficult and less efficient. This in turn leads to a further degradation of the mitochondria, cell structure and function, an increased reliance on fermentation energy, a rise in acid levels, and a drop in oxygen availability: clearly a vicious cycle—a very vicious cycle.

Because ATP production is so much less efficient through fermentation than through respiration, the cell needs much greater amounts of glucose. This forces it to develop a greater sensitivity to it, which forces the formation of more insulin receptors because it is insulin that carries the glucose through the cell wall. And it is, in fact, the case that cancer cells typically have about ten time more insulin receptors than normal cells, and that this makes them ten times more capable of grabbing hold of circulating glucose to sustain themselves. But again, remember that this is yet another adaptation in a struggle for survival without which the cell would die.

Questions, questions and more questions

There is quite a lot more that needs to be addressed and explained. General questions like: How did Warburg figure all this stuff out? And what else did he discover? Specific questions like: Are cancer cells weaker or stronger, more fragile or more resilient? What is it that fundamentally distinguishes them from normal cells? And why does it sometimes take an entire lifetime but at other times just a few years to grow a cancerous tumour? Epidemiological questions like: Why is cancer spreading? Why does it appear more and more in young people? And why does it tend to not only develop but intensify with each generation along family lines? Finally, from all of this detailed information and knowledge, wouldn’t we like to know if there is something to do to prevent or cure cancer? Wouldn’t we like to know what that is: what we can do to prevent and cure it? Of course! That’s our main goal, isn’t it?

We will look at all of these issues and more together, but now I can’t help wonder if the following question, this multi-billion dollar question, might have popped up in your mind while you were reading, as it did for me when I read Warburg’s paper: If he, and by extension, we, as the community of thinking human beings, had understood, explained and demonstrated how cancer arises and then develops in 1956 already, why is it that today, almost 60 years later, cancer rates continue to rise every year, cancer cases appear in people at an increasingly younger age every year, and cancer claims the lives of more people every year than it has ever done? How can this be, and why is it so? Hasn’t anybody else looked at his research and reproduced the results? Haven’t we got today much better instruments and technical means of verifying everything he presented throughout his long career? Don’t worry. We’ll definitely look at that too.

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